Öz
Purpose: The aim of this study was is to compare brain structure volume, including cortical and subcortical regions of adolescents- methamphetamine users versus non-users.
Materials and Methods: The study was designed to be cross-sectional, and structural magnetic resonance imaging scans were obtained from the participants, including ten methamphetamine users and nine non-users. volBrain program was used to evaluate the images.
Results: The results showed that methamphetamine users altered brain structures- temporal, parietal lobes, nucleus accumbens, amygdala, hippocampus, and thalamus volume. Also, the statistically significant difference in the volume between methamphetamine users and non-users was found in subcortical regions except putamen by age. Volumetric analysis of methamphetamine use in adolescents confirms a reduction in temporal lobes (methamphetamine users M±SD=3.43±0.18 non-users M±SD=3.48±0.22) and parietal lobes (methamphetamine users M±SD=2.23±0.24, non-users M±SD=2.37±0.33) in cortical regions in the brain as tissue volume. However, methamphetamine uses caused an increase in volume in the subcortical regions.
Conclusion: Methamphetamine use appears to show decreased volume in the brain regions with age, which has adverse effects on cognitive, emotional, memory, and social abilities.
Anahtar Kelimeler
Methamphetamine brain volume adolescent cortical subcortical regions
Proje Numarası
KÜN.2022-BAGP-017
Kaynakça
- Chomchai C, Chomchai S. Global patterns of methamphetamine use. Curr Opin Psychiatry. 2015;28:269-274.
- Evren C, Bozkurt M. Update on Methamphetamine:an old problem that we have recently encountered. Dusunen Adam. 2018;31:1-10.
- Vearrier D, Greenberg MI, Miller SN, Okaneku JT, Haggerty DA. Methamphetamine: history, pathophysiology, adverse health effects, current trends, and hazards associated with the clandestine manufacture of methamphetamine. Dis Mon. 2012;58:38–89.
- Karakukcu C, Ciraci MZ, Kocer D, Erturk-Zararsiz G, Reyhancan M, Altintop I. Regional drug abuse prevalence depending on laboratory based urine illicit drug screening results. Anadolu Psikiyatri Derg. 2018;19:169-76.
- Gilman JM, Kuster JK, Lee S, Lee MJ, Kim BW, Makris N et al. Cannabis use is quantitatively associated with nucleus accumbens and amygdala abnormalities in young adult recreational users. J Neurosci. 2014;34:5529–38.
- Tapert SF, Schweinsburg AD, Drummond SP, Paulus MP, Brown SA, Yang TT et al. Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology. 2007;194:173–83.
- Paulus MP, Hozack NE, Zauscher BE, Frank L, Brown GG, Braff DL et al. Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects. Neuropsychopharmacology. 2002;26:53-63.
- Jernigan TL, Gamst AC, Archibald SL, Fennema-Notestine C, Mindt MR, Marcotte TD et al. Effects of methamphetamine dependence and HIV infection on cerebral morphology. Am J Psychiatry. 2005;162:1461-72.
- Thompson PM, Hayashi KM, Simon SL, Geaga JA, Hong MS, Sui Y, Lee JY, Toga AW, Ling W, London ED. Structural abnormalities in the brains of human subjects who use methamphetamine. Journal of Neurosci. 2004;24:6028-36.
- Schwartz DL, Mitchell AD, Lahna DL, Luber HS, Huckans MS, Mitchell SH et al. Global and local morphometric differences in recently abstinent methamphetamine-dependent individuals. Neuroimage. 2010;50:1392-401.
- Yuan K, Cheng P, Dong T, Bi Y, Xing L, Yu D et al. Cortical thickness abnormalities in late adolescence with online gaming addiction. PLoS One. 2013;8:e53055.
- Boulos PK, Dalwani MS, Tanabe J, Mikulich-Gilbertson SK, Banich MT, Crowley TJ et al. Brain cortical thickness differences in adolescent females with substance use disorders. PLoS One. 2016;11:e0152983.
- Çolak Ç, Çakmak Çelik Z, Zorlu N, Kitiş Ö, Yüncü Z. Cortical Thickness and Subcortical Volumes in Adolescent Synthetic Cannabinoid Users with or Without ADHD: a Preliminary Study. Arch Neuropsychiatry. 2019;56:167-172.
- Lopez-Larson MP, Bogorodzki P, Rogowska J, McGlade E, King JB, Terry J et al. Altered prefrontal and insular cortical thickness in adolescent marijuana users. Behav Brain Res. 2011;220:164-72.
- Nakama H, Chang L, Fein G, Shimotsu R, Jiang CS, Ernst T. Methamphetamine users show greater than normal age-related cortical gray matter loss. Addiction. 2011;106:1474-1483.
- Henderson KE, Vaidya JG, Kramer JR, Kuperman S, Langbehn DR, O'Leary DS. Cortical thickness in adolescents with a family history of alcohol use disorder. Alcohol Clin Exp Res. 2018;42:89-99.
- Albaugh MD, Ottino-Gonzalez J, Sidwell A, Lepage C, Juliano A, Owens MM et al. Association of cannabis use during adolescence with neurodevelopment. JAMA Psychiatry. 2021;78:91–11.
- Gonzalez R, Rippeth JD, Carey CL, Heaton RK, Moore DJ, Schweinsburg BC et al. Neurocognitive performance of methamphetamine users discordant for history of marijuana exposure. Drug Alcohol Depend. 2004;76:181-90.
- Bulut S, Doğan U, Altundağ Y. Adolescent Psychological Resilience Scale: validity and reliability study. Contemporary Psychology, Suvremena Psihologija. 2013;16:21-32.
- Diener E, Emmons RA, Larsen RJ, Griffin S. The Satisfaction with Life Scale. J Pers Assess. 1985;49:71-5.
- Yetim Ü. Life satisfaction: a study based on the onganization of personal projects. Soc Indic Res. 1993;29:277-89.
- Kern ML, Benson L, Steinberg EA, Steinberg L. The EPOCH Measure of Adolescent Well-Being. Psychol Assess. 2016;28:586–97.
- Demirci İ, Ekşi F. Ergenler İçin Beş Boyutlu İyi Oluş Modeli: EPOCH Ölçeği’nin Türkçe formunun geçerliği ve güvenirliği. Gençlik Araştırmaları Dergisi. 2015;3:9-30.
- Varni JW, Seid M, Rode AC. The Peds QLTM: The measurement model for the pediatric quality of life inventory. Med Care. 1999;37:126-39.
- Memik ÇN, Ağaoğlu B, Coşkun A, Üneri ÖŞ, Karakaya I. Çocuklar için Yaşam Kalitesi Ölçeğinin 13-18 yaş ergen formunun geçerlik ve güvenirliği. Turk Psikiyatri Derg. .2007;18:353-63.
- Chang L, Cloak C, Patterson K, Grob C, Miller EN, Ernst T. Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response. Biol Psychiatry.2005;57:967-74.
- Grant KM, LeVan TD, Wells SM, Li M, Stoltenberg SF, Gendelman HE et al. Methamphetamine associated psychosis. J Neuroimmune Pharmacol. 2012;7:113-39.
- Ujike H, Sato M. Clinical features of sensitization to methamphetamine observed in patients with methamphetamine dependence and psychosis. Ann N Y Acad Sci. 2004;1025:279-87.
- Zweben JE, Cohen JB, Christian D, Galloway GP, Salinardi M, Parent D et al. Methamphetamine Treatment Project. Psychiatric symptoms in methamphetamine users. Am J Addict. 2004;13:181-90.
- Volkow ND, Chang L, Wang GJ, Fowler JS, Franceschi D, Sedler MJ et al. Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. Am J Psychiatry. 2001;158:383-9.
- Wang GJ, Volkow ND, Chang L, Miller E, Sedler M, Hitzemann R et al. Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence. Am J Psychiatry. 2004;161:242-8.
- Zhang Z, He L, Huang S, Fan L, Li Y, Li P et al. Alteration of brain structure with long-term abstinence of methamphetamine by voxel-based morphometry. Front Psychiatry. 2018;9:722.
- Friedman SD, Castaneda E, Hodge GK. Long-term monoamine depletion, differential recovery, and subtle behavioral impairment following methamphetamine-induced neurotoxicity. Pharmacol Biochem Behav. 1998;61;35–44.
- Rothman RB, Partilla JS, Baumann MH, Dersch CM, Carroll FI, Rice KC. Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse. Synapse. 2000;35:222-7.
- Wrase J, Makris N, Braus DF, Mann K, Smolka MN, Kennedy DN et al. Amygdala volume associated with alcohol abuse relapse and craving. Am J Psychiatry. 2008;165:1179-84.
- Durazzo TC, Tosun D, Buckley S, Gazdzinski S, Mon A, Fryer SL et al. Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence. Alcohol Clin Exp Res. 2011;35:1187-200.
- Korponay C, Kosson DS, Decety J, Kiehl KA, Koenigs M. Brain volume correlates with duration of abstinence from substance abuse in a region-specific and substance-specific manner. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2:626-35
Metamfetamin kullanan ergenlerin kortikal ve subkortikal beyin hacim değişimlerinin nörogörüntüleme çalışması
Öz
Amaç: Bu çalışma metamfetamin kullanan ve kullanmayan ergenlerin beyin kortikal ve subkortikal bölgeleri dahil olmak üzere beyin yapı hacimlerini karşılaştırmayı amaçlamıştır.
Gereç ve Yöntem: Kesitsel olarak tasarlanan bu çalışmaya on metamfetamin kullanan ve dokuz metamfetamin kullanmayan ergenler dahil edilmiştir. Katılımcıların beyin görüntüleri magnetik rezonans görüntüleme cihazı ile elde edilmiş ve görüntülerin analizi volBrain program aracılığıyla yapılmıştır.
Bulgular: Sonuçlar metamfetamin kullanıcılarının temporal, parietal, nükleus akkumbens, amigdala, hipokampüs ve talamus bölgelerinde hacimsel değişikler olduğunu göstermiştir. Ayrıca, metamfetamin kullanan ve kullanmayanların subkortikal bölgelerinde, putamen bölgesi dışında, hacimsel değişikliğin yaşa göre istatistiksel anlamlılık gösterdiği bulunmuştur. Ergenlerde metamfetamin kullanımına ilişkin hacimsel analiz sonucunda temporal lobda (metamfetamin kullananlar M±SD=3.43±0.18, kullanmayanlar M±SD=3.48±0.22) ve parietal lobda (metamfetamin kullananlar M±SD=2.23±0.24, kullanmayanlar M±SD=2.37±0.33) hacimsel azalma olduğunu tespit edilmiştir. Ancak metamfetamin kullanımı subkortikal bölgelerde hacim artışına neden olmuştur.
Sonuç: Metamfetamin kullanımın yaşa bağlı olarak beyin bölgelerinde hacimsel değişime neden olduğu, bununla beraber kullanıcıların bilişsel, duygusal, hafıza ve sosyal becerileri üzerinde olumsuz etkiler oluşturduğu söylenebilir.
Anahtar Kelimeler
Metamfetamin Beyin hacmi Ergen Kortikal Subkortikal bölgeler
Destekleyen Kurum
Kapadokya Üniversitesi
Proje Numarası
KÜN.2022-BAGP-017
Teşekkür
Çalışmaya destek veren Prof. Dr. Müge Artar ve Erciyes Üniversitesi Radyoloji Ana bilim dalı öğretim üyeleri Prof. Dr. Halil Sönmez ve Dr. Öğr. Üyesi İzzet Ökçesiz ile Öğr. Gör. Hüseyin Yiğit e teşekür ederim.
Kaynakça
- Chomchai C, Chomchai S. Global patterns of methamphetamine use. Curr Opin Psychiatry. 2015;28:269-274.
- Evren C, Bozkurt M. Update on Methamphetamine:an old problem that we have recently encountered. Dusunen Adam. 2018;31:1-10.
- Vearrier D, Greenberg MI, Miller SN, Okaneku JT, Haggerty DA. Methamphetamine: history, pathophysiology, adverse health effects, current trends, and hazards associated with the clandestine manufacture of methamphetamine. Dis Mon. 2012;58:38–89.
- Karakukcu C, Ciraci MZ, Kocer D, Erturk-Zararsiz G, Reyhancan M, Altintop I. Regional drug abuse prevalence depending on laboratory based urine illicit drug screening results. Anadolu Psikiyatri Derg. 2018;19:169-76.
- Gilman JM, Kuster JK, Lee S, Lee MJ, Kim BW, Makris N et al. Cannabis use is quantitatively associated with nucleus accumbens and amygdala abnormalities in young adult recreational users. J Neurosci. 2014;34:5529–38.
- Tapert SF, Schweinsburg AD, Drummond SP, Paulus MP, Brown SA, Yang TT et al. Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology. 2007;194:173–83.
- Paulus MP, Hozack NE, Zauscher BE, Frank L, Brown GG, Braff DL et al. Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects. Neuropsychopharmacology. 2002;26:53-63.
- Jernigan TL, Gamst AC, Archibald SL, Fennema-Notestine C, Mindt MR, Marcotte TD et al. Effects of methamphetamine dependence and HIV infection on cerebral morphology. Am J Psychiatry. 2005;162:1461-72.
- Thompson PM, Hayashi KM, Simon SL, Geaga JA, Hong MS, Sui Y, Lee JY, Toga AW, Ling W, London ED. Structural abnormalities in the brains of human subjects who use methamphetamine. Journal of Neurosci. 2004;24:6028-36.
- Schwartz DL, Mitchell AD, Lahna DL, Luber HS, Huckans MS, Mitchell SH et al. Global and local morphometric differences in recently abstinent methamphetamine-dependent individuals. Neuroimage. 2010;50:1392-401.
- Yuan K, Cheng P, Dong T, Bi Y, Xing L, Yu D et al. Cortical thickness abnormalities in late adolescence with online gaming addiction. PLoS One. 2013;8:e53055.
- Boulos PK, Dalwani MS, Tanabe J, Mikulich-Gilbertson SK, Banich MT, Crowley TJ et al. Brain cortical thickness differences in adolescent females with substance use disorders. PLoS One. 2016;11:e0152983.
- Çolak Ç, Çakmak Çelik Z, Zorlu N, Kitiş Ö, Yüncü Z. Cortical Thickness and Subcortical Volumes in Adolescent Synthetic Cannabinoid Users with or Without ADHD: a Preliminary Study. Arch Neuropsychiatry. 2019;56:167-172.
- Lopez-Larson MP, Bogorodzki P, Rogowska J, McGlade E, King JB, Terry J et al. Altered prefrontal and insular cortical thickness in adolescent marijuana users. Behav Brain Res. 2011;220:164-72.
- Nakama H, Chang L, Fein G, Shimotsu R, Jiang CS, Ernst T. Methamphetamine users show greater than normal age-related cortical gray matter loss. Addiction. 2011;106:1474-1483.
- Henderson KE, Vaidya JG, Kramer JR, Kuperman S, Langbehn DR, O'Leary DS. Cortical thickness in adolescents with a family history of alcohol use disorder. Alcohol Clin Exp Res. 2018;42:89-99.
- Albaugh MD, Ottino-Gonzalez J, Sidwell A, Lepage C, Juliano A, Owens MM et al. Association of cannabis use during adolescence with neurodevelopment. JAMA Psychiatry. 2021;78:91–11.
- Gonzalez R, Rippeth JD, Carey CL, Heaton RK, Moore DJ, Schweinsburg BC et al. Neurocognitive performance of methamphetamine users discordant for history of marijuana exposure. Drug Alcohol Depend. 2004;76:181-90.
- Bulut S, Doğan U, Altundağ Y. Adolescent Psychological Resilience Scale: validity and reliability study. Contemporary Psychology, Suvremena Psihologija. 2013;16:21-32.
- Diener E, Emmons RA, Larsen RJ, Griffin S. The Satisfaction with Life Scale. J Pers Assess. 1985;49:71-5.
- Yetim Ü. Life satisfaction: a study based on the onganization of personal projects. Soc Indic Res. 1993;29:277-89.
- Kern ML, Benson L, Steinberg EA, Steinberg L. The EPOCH Measure of Adolescent Well-Being. Psychol Assess. 2016;28:586–97.
- Demirci İ, Ekşi F. Ergenler İçin Beş Boyutlu İyi Oluş Modeli: EPOCH Ölçeği’nin Türkçe formunun geçerliği ve güvenirliği. Gençlik Araştırmaları Dergisi. 2015;3:9-30.
- Varni JW, Seid M, Rode AC. The Peds QLTM: The measurement model for the pediatric quality of life inventory. Med Care. 1999;37:126-39.
- Memik ÇN, Ağaoğlu B, Coşkun A, Üneri ÖŞ, Karakaya I. Çocuklar için Yaşam Kalitesi Ölçeğinin 13-18 yaş ergen formunun geçerlik ve güvenirliği. Turk Psikiyatri Derg. .2007;18:353-63.
- Chang L, Cloak C, Patterson K, Grob C, Miller EN, Ernst T. Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response. Biol Psychiatry.2005;57:967-74.
- Grant KM, LeVan TD, Wells SM, Li M, Stoltenberg SF, Gendelman HE et al. Methamphetamine associated psychosis. J Neuroimmune Pharmacol. 2012;7:113-39.
- Ujike H, Sato M. Clinical features of sensitization to methamphetamine observed in patients with methamphetamine dependence and psychosis. Ann N Y Acad Sci. 2004;1025:279-87.
- Zweben JE, Cohen JB, Christian D, Galloway GP, Salinardi M, Parent D et al. Methamphetamine Treatment Project. Psychiatric symptoms in methamphetamine users. Am J Addict. 2004;13:181-90.
- Volkow ND, Chang L, Wang GJ, Fowler JS, Franceschi D, Sedler MJ et al. Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. Am J Psychiatry. 2001;158:383-9.
- Wang GJ, Volkow ND, Chang L, Miller E, Sedler M, Hitzemann R et al. Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence. Am J Psychiatry. 2004;161:242-8.
- Zhang Z, He L, Huang S, Fan L, Li Y, Li P et al. Alteration of brain structure with long-term abstinence of methamphetamine by voxel-based morphometry. Front Psychiatry. 2018;9:722.
- Friedman SD, Castaneda E, Hodge GK. Long-term monoamine depletion, differential recovery, and subtle behavioral impairment following methamphetamine-induced neurotoxicity. Pharmacol Biochem Behav. 1998;61;35–44.
- Rothman RB, Partilla JS, Baumann MH, Dersch CM, Carroll FI, Rice KC. Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse. Synapse. 2000;35:222-7.
- Wrase J, Makris N, Braus DF, Mann K, Smolka MN, Kennedy DN et al. Amygdala volume associated with alcohol abuse relapse and craving. Am J Psychiatry. 2008;165:1179-84.
- Durazzo TC, Tosun D, Buckley S, Gazdzinski S, Mon A, Fryer SL et al. Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence. Alcohol Clin Exp Res. 2011;35:1187-200.
- Korponay C, Kosson DS, Decety J, Kiehl KA, Koenigs M. Brain volume correlates with duration of abstinence from substance abuse in a region-specific and substance-specific manner. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2:626-35
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Radyoloji ve Organ Görüntüleme |
| Bölüm | Araştırma |
| Yazarlar | |
| Proje Numarası | KÜN.2022-BAGP-017 |
| Erken Görünüm Tarihi | 27 Eylül 2023 |
| Yayımlanma Tarihi | 30 Eylül 2023 |
| Kabul Tarihi | 21 Eylül 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 48 Sayı: 3 |
